Modular COVID-19 Testing Booths Help Thai Hospitals Reach More People During Pandemic
The swift establishment of modular COVID-19 testing booths helped hospitals to keep check of the pandemic’s reach in the cities and remote areas of Thailand.
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Analyzing Binding Kinetics: Which Method Is Best for Your Next SPR Experiment?
Read on to learn about the two most common approaches for measuring binding kinetics, multi-cycle kinetics (MCK) and single-cycle kinetics (SCK), and how to select the right one for your interaction.
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Surface Plasmon Resonance Sensors: A Comprehensive Guide for Scientists
SPR is a label-free technique that enables you to get in depth information on how two biomolecules are interacting. This is done on a sensor inside of an instrument such as the OpenSPR or Alto. SPR instruments are primarily used to measure binding affinity and kinetics, and are becoming increasingly more affordable and accessible as researchers realize the value that SPR data can bring to their research.
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Ask an Expert: Efficient Development of Gene Therapy and Vaccines Through Comprehensive Viral Vector Characterization
Ever-more structurally complex bio-molecules and biological entities are coming into focus within the pharma development space, with fit-for-purpose analytics becoming more important to their success. Reducing development time and optimising formulation through applying orthogonal analytical technologies is key to bringing them to market in an efficient, risk-free manner. Date recorded: June 22, 2021 In addition…
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Synthesis and Characterization of Antibody Drug Conjugates
Antibody drug conjugates (ADCs) are attracting a tremendous amount of attention because they have the potential to revolutionize cancer treatment. Chemical ligation of cytotoxic agents to monoclonal antibodies allows the selective delivery of cytotoxins to tumor cells thereby potentially mitigating some of the damaging side-effects of cancer chemotherapy. There are currently nine FDA-approved ADCs and…
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Target Selectivity of Multispecific Antibodies: Practical Analysis of Binding Kinetics and Avidity
Bispecific antibodies are promising therapeutics for targeting cancer cells with high specificity.
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Insights Into Multi Fluorescence NTA Based EV Characterization – ISEV ‘EV Imaging in Vivo’ Workshop
Nanoparticle Tracking Analysis (NTA) with the Particle Metrix ZetaView® instrument family allows fast and reliable measurement of size, concentration, and Zeta Potential of nanoparticles. In contrast to scatter-based particle detection, fluorescence detection capability of the ZetaView® instrument allows the user to get biochemical information about particles. This increases the resolution and discriminatory power of the data. Furthermore,…
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The pH Value Is a Key Factor in Cell and Tissue Cultures
The term ‘pH’ is derived from either ‘pondus hydrogenii’ or ‘potentia hydrogenii.’ Both are originally Latin phrases, with ‘pondus hydrogenii’ meaning ‘weight of hydrogen’ and ‘potentia hydrogenii’ meaning ‘power of hydrogen.’ The pH value is a non-dimensional number that measures how acidic or alkaline an aqueous solution is. It is defined as the negative decimal logarithm of the concentration of hydrogen ions. The strength of the acid or alkali is identified by color indicators.
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Live Cell Imaging – An Overview for Beginners
Live cell imaging is a widely-used microscopy technique to study the behavior and the function of living cells in real time. It is indispensable for achieving a better understanding of the biological dynamics within cells, which cannot be properly analyzed using microscopy of fixed samples. Topics that can be addressed using live cell microscopy include the study of cell migration, the analysis of cell-cell-interaction, and the monitoring of molecule localization, among others.
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Moving from 2D to 3D – Advanced Tools from Ibidi
Cell culture assays with two-dimensional monolayers have been a well-established and convenient tool for investigating cell behavior and function in many areas of cell biology, such as cancer biology and stem cell research. However, these 2D assays come with certain limitations, since they do not accurately reflect the in vivo cell-to-cell interactions. Because of these limitations, 3D cell culture models have gained more and more relevance, as they have been proven to yield more accurate insights and data about cell function, structure, and morphology.
