Biomolecular characterization

The OpenSPR platform has been leveraged in over 200 peer-reviewed publications, providing high-quality binding data for applications in dugdiscovery, disease research, diagnostics and more. In this paper researchers for The University of Kansas reviewed OpenSPR publications to investigate the range of biomolecular analytes and interactions studied, most common applications and representative research highlighting OpenSPR’s flexibility and utility.

Lipid nanoparticles (LNPs) have received a huge amount of attention in recent years due their advanced capability to deliver biotherapeutics and active pharmaceutical ingredients (APIs) into cells within living systems. LNPs can be produced in a reproducible manner on the Nadia Innovate which makes it the ideal platform for early-stage research to identify therapeutic targets.

Oligonucleotides offer a promising approach for the development of vaccines and therapeutics, including for gene expression conditions. Tools that accurately characterize these molecules are imperative for continued progress of life-saving research. In this application note, we demonstrate OpenSPR’s applicability in characterizing sequences of complementary oligonucleotides by measuring binding affinity and kinetics with accuracy, precision and reproducibility.